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Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Ligand
BDBM267016
Substrate
n/a
Meas. Tech.
PFKFB4 Assay
IC50
2800±n/a nM
Citation
 Martinsson, J; Faernegardh, K; Joensson, M; Ringom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent  US9718809 Publication Date 8/1/2017 
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Synonyms:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4
Type:
Enzyme
Mol. Mass.:
54039.68
Organism:
Homo sapiens (Human)
Description:
Q16877
Residue:
469
Sequence:
MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
  
Inhibitor
Name:
BDBM267016
Synonyms:
Methyl 4-({[4-(3-aminophenyl)-5-chlorothiophen-2-yl]sulfonyl}amino)-2-hydroxybenzoate trifluoroacetate | US9718809, 107
Type:
Small organic molecule
Emp. Form.:
C18H15ClN2O5S2
Mol. Mass.:
438.905
SMILES:
COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(N)c2)cc1O
Structure:
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