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Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Ligand
BDBM267051
Substrate
n/a
Meas. Tech.
PFKFB4 Assay
IC50
2800±n/a nM
Citation
 Martinsson, J; Faernegardh, K; Joensson, M; Ringom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent  US9718809 Publication Date 8/1/2017 
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Synonyms:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4
Type:
Enzyme
Mol. Mass.:
54039.68
Organism:
Homo sapiens (Human)
Description:
Q16877
Residue:
469
Sequence:
MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
  
Inhibitor
Name:
BDBM267051
Synonyms:
3-Morpholin-4-ylpropyl 4-({[4-(1,3-benzodioxol-5-yl)-5-chloro-2-thienyl]sulfonyl}amino)-2-hydroxybenzoate trifluoroacetate | US9718809, 162
Type:
Small organic molecule
Emp. Form.:
C25H25ClN2O8S2
Mol. Mass.:
581.058
SMILES:
Oc1cc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccc3OCOc3c2)ccc1C(=O)OCCCN1CCOCC1
Structure:
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