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Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Ligand
BDBM267067
Substrate
n/a
Meas. Tech.
PFKFB4 Assay
IC50
3500±n/a nM
Citation
 Martinsson, J; Faernegardh, K; Joensson, M; Ringom, R Bisarylsulfonamides useful in the treatment of inflammation and cancer US Patent  US9718809 Publication Date 8/1/2017 
Target
Name:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Synonyms:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) | F264_HUMAN | PFKFB4
Type:
Enzyme
Mol. Mass.:
54039.68
Organism:
Homo sapiens (Human)
Description:
Q16877
Residue:
469
Sequence:
MASPRELTQNPLKKIWMPYSNGRPALHACQRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDVVKTYKSFEFFLPDNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDNYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ
  
Inhibitor
Name:
BDBM267067
Synonyms:
2-Methoxyethyl 4-{[(4-bromo-2,5-dichlorothiophen-3-yl)sulfonyl]amino}-2-hydroxybenzoate | US9718809, 197
Type:
Small organic molecule
Emp. Form.:
C14H12BrCl2NO6S2
Mol. Mass.:
505.188
SMILES:
COCCOC(=O)c1ccc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Br)cc1O
Structure:
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