Reaction Details Report a problem with these data
Target
Transcription factor p65
Ligand
BDBM49560
Substrate
n/a
Meas. Tech.
Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response
EC50
1928±n/a nM
Citation
 PubChem, PC Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
Transcription factor p65
Synonyms:
NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1
Type:
Enzyme
Mol. Mass.:
60211.92
Organism:
Homo sapiens (Human)
Description:
Q04206
Residue:
551
Sequence:
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM49560
Synonyms:
(4-methylphenyl) N-[3-(diethylcarbamothioylsulfanyl)propanoyl]carbamate | 4-methylphenyl (3-{[(diethylamino)carbonothioyl]thio}propanoyl)carbamate | MLS000573486 | N-[3-(diethylthiocarbamoylthio)propanoyl]carbamic acid p-tolyl ester | N-[3-[[diethylamino(sulfanylidene)methyl]thio]-1-oxopropyl]carbamic acid (4-methylphenyl) ester | SMR000194988 | cid_2282573
Type:
Small organic molecule
Emp. Form.:
C16H22N2O3S2
Mol. Mass.:
354.487
SMILES:
CCN(CC)C(=S)SCCC(=O)NC(=O)Oc1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: