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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50543
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
3664.545062±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50543
Synonyms:
3-[(3-chloro-1,4-diketo-2-naphthyl)amino]benzoic acid | 3-[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]benzoic acid | 3-[(3-chloro-1,4-dioxo-2-naphthalenyl)amino]benzoic acid | 3-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]benzoic acid | 3-[[3-chloranyl-1,4-bis(oxidanylidene)naphthalen-2-yl]amino]benzoic acid | MLS000689606 | SMR000312850 | cid_470958
Type:
Small organic molecule
Emp. Form.:
C17H10ClNO4
Mol. Mass.:
327.719
SMILES:
OC(=O)c1cccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)c1 |c:9|
Structure:
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