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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50699
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
4673.597032±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50699
Synonyms:
(2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-3H-1,3-thiazol-2-ylidene]-3-(3-nitro-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)propanenitrile | (2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-3H-1,3-thiazol-2-ylidene]-3-(3-nitro-4-oxocyclohexa-2,5-dien-1-ylidene)propanenitrile | (2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-3H-thiazol-2-ylidene]-3-(3-nitro-4-oxo-1-cyclohexa-2,5-dienylidene)propanenitrile | (2Z,3Z)-2-[4-(3,4-dimethoxyphenyl)-4-thiazolin-2-ylidene]-3-(4-keto-3-nitro-cyclohexa-2,5-dien-1-ylidene)propionitrile | (E)-2-[4-(3,4-Dimethoxy-phenyl)-thiazol-2-yl]-3-(4-hydroxy-3-nitro-phenyl)-acrylonitrile | MLS000777382 | SMR000413866 | cid_16682695
Type:
Small organic molecule
Emp. Form.:
C20H15N3O5S
Mol. Mass.:
409.415
SMILES:
COc1ccc(cc1OC)-c1csc([nH+]1)C(=C\[c-]1ccc(=O)c(c1)[N+]([O-])=O)\C#N
Structure:
Search PDB for entries with ligand similarity: