Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM34599
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay
EC50
100000±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM34599
Synonyms:
1-[5-chloranyl-2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-3-(6-morpholin-4-ylpyrimidin-4-yl)urea | 1-[5-chloro-2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-3-(6-morpholin-4-ylpyrimidin-4-yl)urea | 1-[5-chloro-2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-3-(6-morpholinopyrimidin-4-yl)urea | 1-[5-chloro-2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-3-[6-(4-morpholinyl)-4-pyrimidinyl]urea | MLS000085600 | N-[5-chloro-2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-N'-(6-morpholin-4-ylpyrimidin-4-yl)urea | SMR000020535 | cid_3236557
Type:
Small organic molecule
Emp. Form.:
C17H15ClF3N5O4
Mol. Mass.:
445.78
SMILES:
FC(F)(F)C1(NC(=O)Nc2cc(ncn2)N2CCOCC2)Oc2ccc(Cl)cc2O1
Structure:
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