Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46764
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
5210±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46764
Synonyms:
(4Z)-4-[1-(dimethylamino)ethylidene]-2-(4-nitrophenyl)-5-phenyl-2-pyrazolin-3-one | (4Z)-4-[1-(dimethylamino)ethylidene]-2-(4-nitrophenyl)-5-phenyl-3-pyrazolone | (4Z)-4-[1-(dimethylamino)ethylidene]-2-(4-nitrophenyl)-5-phenyl-pyrazol-3-one | (4Z)-4-[1-(dimethylamino)ethylidene]-2-(4-nitrophenyl)-5-phenylpyrazol-3-one | 4-[1-(dimethylamino)ethylidene]-2-(4-nitrophenyl)-5-phenyl-2,4-dihydro-3H-pyrazol-3-one | MLS000570894 | SMR000193317 | cid_2870907
Type:
Small organic molecule
Emp. Form.:
C19H18N4O3
Mol. Mass.:
350.3712
SMILES:
[#6]\[#6](-c1c([n-]n(-c2ccc(cc2)-[#7+](-[#8-])=O)c1=O)-c1ccccc1)=[#7+](/[#6])-[#6]
Structure:
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