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Target
Mucolipin-3
Ligand
BDBM42052
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
29900±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM42052
Synonyms:
2-N,3-N-dimethyl-6,7-dinitroquinoxaline-2,3-diamine | MLS000579073 | N,N'-(6,7-dinitro-1,4-dihydroquinoxaline-2,3-diylidene)dimethanamine | N2,N3-dimethyl-6,7-dinitro-quinoxaline-2,3-diamine | N2,N3-dimethyl-6,7-dinitroquinoxaline-2,3-diamine | SMR000186662 | cid_4686258 | methyl-[3-(methylamino)-6,7-dinitro-quinoxalin-2-yl]amine
Type:
Small organic molecule
Emp. Form.:
C10H10N6O4
Mol. Mass.:
278.2242
SMILES:
CNc1nc2cc(c(cc2nc1NC)[N+]([O-])=O)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: