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Target
Mucolipin-3
Ligand
BDBM46778
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
29900±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46778
Synonyms:
7-bromanyl-3,4-dihydro-2H-1,5-benzodioxepine-8-carboxylic acid | 7-bromo-3,4-dihydro-2H-1,5-benzodioxepin-8-carboxylic acid | 7-bromo-3,4-dihydro-2H-1,5-benzodioxepine-8-carboxylic acid | 8-bromo-3,4-dihydro-2H-1,5-benzodioxepine-7-carboxylic acid | MLS000704762 | SMR000231392 | cid_5045885
Type:
Small organic molecule
Emp. Form.:
C10H9BrO4
Mol. Mass.:
273.08
SMILES:
OC(=O)c1cc2OCCCOc2cc1Br
Structure:
Search PDB for entries with ligand similarity: