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Target
Mucolipin-3
Ligand
BDBM46790
Substrate
n/a
Meas. Tech.
Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
5420±n/a nM
Citation
 PubChem, PC Fluorescence counterscreen assay for TRPN1 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46790
Synonyms:
2-[4-(1H-indol-2-ylmethyl)-1-(3-methoxybenzyl)piperazin-2-yl]ethanol | 2-[4-(1H-indol-2-ylmethyl)-1-[(3-methoxyphenyl)methyl]-2-piperazinyl]ethanol | 2-[4-(1H-indol-2-ylmethyl)-1-[(3-methoxyphenyl)methyl]piperazin-2-yl]ethanol | 2-[4-(1H-indol-2-ylmethyl)-1-m-anisyl-piperazin-2-yl]ethanol | MLS000732745 | SMR000316628 | cid_16190433
Type:
Small organic molecule
Emp. Form.:
C23H29N3O2
Mol. Mass.:
379.4953
SMILES:
COc1cccc(CN2CCN(Cc3cc4ccccc4[nH]3)CC2CCO)c1
Structure:
Search PDB for entries with ligand similarity: