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Target
Beta-lactamase
Ligand
BDBM51973
Substrate
n/a
Meas. Tech.
FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
43086±n/a nM
Citation
 PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM51973
Synonyms:
(E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloranyl-5-nitro-phenyl)pent-4-enoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloro-5-nitro-phenyl)pent-4-enoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloro-5-nitrophenyl)-4-pentenoic acid | (E)-4-(1,3-benzothiazol-2-yl)-5-(2-chloro-5-nitrophenyl)pent-4-enoic acid | MLS000416514 | SMR000243458 | cid_6236321
Type:
Small organic molecule
Emp. Form.:
C18H13ClN2O4S
Mol. Mass.:
388.825
SMILES:
OC(=O)CC\C(=C/c1cc(ccc1Cl)[N+]([O-])=O)c1nc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: