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Target
Beta-lactamase
Ligand
BDBM51975
Substrate
n/a
Meas. Tech.
FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.
IC50
59640±n/a nM
Citation
 PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay (2009)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM51975
Synonyms:
6-(2-methylpropyl)-4-[1-(6-methylpyridin-2-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carbonyl]-1H-pyrimidin-2-one | 6-(2-methylpropyl)-4-[[1-(6-methyl-2-pyridinyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-oxomethyl]-1H-pyrimidin-2-one | 6-(2-methylpropyl)-4-[[1-(6-methylpyridin-2-yl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]carbonyl]-1H-pyrimidin-2-one | 6-isobutyl-4-[1-(6-methyl-2-pyridyl)-1,3,4,9-tetrahydro-beta-carboline-2-carbonyl]-1H-pyrimidin-2-one | 6-isobutyl-4-{[1-(6-methylpyridin-2-yl)-1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl]carbonyl}pyrimidin-2(1H)-one | MLS000862704 | SMR000319578 | cid_16187921
Type:
Small organic molecule
Emp. Form.:
C26H27N5O2
Mol. Mass.:
441.5249
SMILES:
CC(C)Cc1cc([nH]c(=O)n1)C(=O)N1CCc2c([nH]c3ccccc23)C1c1cccc(C)n1
Structure:
Search PDB for entries with ligand similarity: