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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53447
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
4.7e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCH-L3 | UCHL3_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) | Ubiquitin thioesterase L3 | Uchl3
Type:
Protein
Mol. Mass.:
26139.77
Organism:
Mus musculus (Mouse)
Description:
Q9JKB1
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53447
Synonyms:
4,4'-[1,4-phenylenebis(oxy)]diphenol | 4-[4-(4-hydroxyphenoxy)phenoxy]phenol | 4-[4-(4-oxidanylphenoxy)phenoxy]phenol | MLS001162917 | O-acyl oxime isatin derivative, 13 | SMR000495822 | cid_786365
Type:
Small organic molecule
Emp. Form.:
C18H14O4
Mol. Mass.:
294.3014
SMILES:
Oc1ccc(Oc2ccc(Oc3ccc(O)cc3)cc2)cc1
Structure:
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