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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53469
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
1.6e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCH-L3 | UCHL3_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) | Ubiquitin thioesterase L3 | Uchl3
Type:
Protein
Mol. Mass.:
26139.77
Organism:
Mus musculus (Mouse)
Description:
Q9JKB1
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53469
Synonyms:
MLS001209351 | N-[1-(4-Bromo-phenyl)-ethylidene]-N'-(2-methyl-6-piperidin-1-yl-pyrimidin-4-yl)-hydrazine | N-[1-(4-bromophenyl)ethylideneamino]-2-methyl-6-(1-piperidinyl)-4-pyrimidinamine | N-[1-(4-bromophenyl)ethylideneamino]-2-methyl-6-piperidin-1-yl-pyrimidin-4-amine | N-[1-(4-bromophenyl)ethylideneamino]-2-methyl-6-piperidin-1-ylpyrimidin-4-amine | O-acyl oxime isatin derivative, 52 | SMR000513418 | [1-(4-bromophenyl)ethylideneamino]-(2-methyl-6-piperidino-pyrimidin-4-yl)amine | cid_3099302
Type:
Small organic molecule
Emp. Form.:
C18H22BrN5
Mol. Mass.:
388.305
SMILES:
CC(N=Nc1cc(nc(C)n1)N1CCCCC1)c1ccc(Br)cc1 |w:3.3|
Structure:
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