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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53471
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
7.6±0
Temperature
298.15±0 K
IC50
7.2e+4±n/a nM
Citation
 Liu, Y; Lashuel, HA; Choi, S; Xing, X; Case, A; Ni, J; Yeh, LA; Cuny, GD; Stein, RL; Lansbury, PT Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCH-L3 | UCHL3_MOUSE | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) | Ubiquitin thioesterase L3 | Uchl3
Type:
Protein
Mol. Mass.:
26139.77
Organism:
Mus musculus (Mouse)
Description:
Q9JKB1
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53471
Synonyms:
(3-Ethyl-5-hydroxy-5-phenyl-4,5-dihydro-pyrazol-1-yl)-(2-hydroxy-phenyl)-methanone | (3-ethyl-5-hydroxy-5-phenyl-2-pyrazolin-1-yl)-(2-hydroxyphenyl)methanone | (3-ethyl-5-hydroxy-5-phenyl-4H-pyrazol-1-yl)-(2-hydroxyphenyl)methanone | (3-ethyl-5-oxidanyl-5-phenyl-4H-pyrazol-1-yl)-(2-hydroxyphenyl)methanone | MLS001209409 | O-acyl oxime isatin derivative, 14 | SMR000513369 | cid_3098837
Type:
Small organic molecule
Emp. Form.:
C18H18N2O3
Mol. Mass.:
310.3471
SMILES:
CCC1=NN(C(=O)c2ccccc2O)C(O)(C1)c1ccccc1 |t:2|
Structure:
Search PDB for entries with ligand similarity: