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Target
M1 family aminopeptidase
Ligand
BDBM39915
Substrate
n/a
Meas. Tech.
Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP)
IC50
5580±n/a nM
Citation
 PubChem, PC Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP) PubChem Bioassay (2008)[AID] 
Target
Name:
M1 family aminopeptidase
Synonyms:
AMPN_PLAF7 | M1AAP | Zinc aminopeptidase | m1-family aminopeptidase
Type:
PROTEIN
Mol. Mass.:
126072.31
Organism:
Plasmodium falciparum (isolate FcB1 / Columbia)
Description:
ChEMBL_735637
Residue:
1085
Sequence:
MKLTKGCAYKYIIFTVLILANILYDNKKRCMIKKNLRISSCGIISRLLKSNSNYNSFNKNYNFTSAISELQFSNFWNLDILQKDIFSNIHNNKNKPQSYIIHKRLMSEKGDNNNNNHQNNNGNDNKKRLGSVVNNEENTCSDKRMKPFEEGHGITQVDKMNNNSDHLQQNGVMNLNSNNVENNNNNNSVVVKKNEPKIHYRKDYKPSGFIINNVTLNINIHDNETIVRSVLDMDISKHNVGEDLVFDGVGLKINEISINNKKLVEGEEYTYDNEFLTIFSKFVPKSKFAFSSEVIIHPETNYALTGLYKSKNIIVSQCEATGFRRITFFIDRPDMMAKYDVTVTADKEKYPVLLSNGDKVNEFEIPGGRHGARFNDPHLKPCYLFAVVAGDLKHLSATYITKYTKKKVELYVFSEEKYVSKLQWALECLKKSMAFDEDYFGLEYDLSRLNLVAVSDFNVGAMENKGLNIFNANSLLASKKNSIDFSYARILTVVGHEYFHNYTGNRVTLRDWFQLTLKEGLTVHRENLFSEEMTKTVTTRLSHVDLLRSVQFLEDSSPLSHPIRPESYVSMENFYTTTVYDKGSEVMRMYLTILGEEYYKKGFDIYIKKNDGNTATCEDFNYAMEQAYKMKKADNSANLNQYLLWFSQSGTPHVSFKYNYDAEKKQYSIHVNQYTKPDENQKEKKPLFIPISVGLINPENGKEMISQTTLELTKESDTFVFNNIAVKPIPSLFRGFSAPVYIEDNLTDEERILLLKYDSDAFVRYNSCTNIYMKQILMNYNEFLKAKNEKLESFNLTPVNAQFIDAIKYLLEDPHADAGFKSYIVSLPQDRYIINFVSNLDTDVLADTKEYIYKQIGDKLNDVYYKMFKSLEAKADDLTYFNDESHVDFDQMNMRTLRNTLLSLLSKAQYPNILNEIIEHSKSPYPSNWLTSLSVSAYFDKYFELYDKTYKLSKDDELLLQEWLKTVSRSDRKDIYEILKKLENEVLKDSKNPNDIRAVYLPFTNNLRRFHDISGKGYKLIAEVITKTDKFNPMVATQLCEPFKLWNKLDTKRQELMLNEMNTMLQEPNISNNLKEYLLRLTNKL
  
Inhibitor
Name:
BDBM39915
Synonyms:
2-[(5-chloro-2-hydroxy-anilino)methylene]-5-(2-furyl)cyclohexane-1,3-quinone | 2-[(5-chloro-2-hydroxyanilino)methylidene]-5-(2-furanyl)cyclohexane-1,3-dione | 2-[(5-chloro-2-hydroxyanilino)methylidene]-5-(furan-2-yl)cyclohexane-1,3-dione | 2-[[(5-chloranyl-2-oxidanyl-phenyl)amino]methylidene]-5-(furan-2-yl)cyclohexane-1,3-dione | MLS000037985 | SMR000039816 | cid_658836
Type:
Small organic molecule
Emp. Form.:
C17H14ClNO4
Mol. Mass.:
331.75
SMILES:
Oc1ccc(Cl)cc1NC=C1C(=O)CC(CC1=O)c1ccco1 |(3.91,-3.81,;5.24,-4.58,;5.24,-6.12,;6.57,-6.89,;7.91,-6.12,;9.24,-6.89,;7.91,-4.58,;6.57,-3.81,;6.57,-2.27,;7.91,-1.5,;7.91,.04,;6.57,.81,;5.24,.04,;6.57,2.35,;7.91,3.12,;9.24,2.35,;9.24,.81,;10.58,.04,;8.68,4.45,;8.05,5.86,;9.2,6.89,;10.53,6.12,;10.21,4.61,)|
Structure:
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