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Target
Nucleotide-binding oligomerization domain-containing protein 2
Ligand
BDBM54226
Substrate
n/a
Meas. Tech.
uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells
IC50
2289±n/a nM
Citation
 PubChem, PC uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells PubChem Bioassay (2010)[AID] 
Target
Name:
Nucleotide-binding oligomerization domain-containing protein 2
Synonyms:
CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 | nucleotide-binding oligomerization domain containing 2
Type:
PROTEIN
Mol. Mass.:
115287.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454053
Residue:
1040
Sequence:
MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLHGCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRLLL
  
Inhibitor
Name:
BDBM54226
Synonyms:
(3-amino-7-methoxy-1-pyrazolo[3,4-b]quinolinyl)-(4-chloro-3-nitrophenyl)methanone | (3-amino-7-methoxy-pyrazolo[3,4-b]quinolin-1-yl)-(4-chloro-3-nitro-phenyl)methanone | (3-amino-7-methoxypyrazolo[3,4-b]quinolin-1-yl)-(4-chloro-3-nitrophenyl)methanone | (3-azanyl-7-methoxy-pyrazolo[3,4-b]quinolin-1-yl)-(4-chloranyl-3-nitro-phenyl)methanone | 1-(4-chloro-3-nitrobenzoyl)-7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine | MLS000582480 | SMR000206466 | cid_12004545
Type:
Small organic molecule
Emp. Form.:
C18H12ClN5O4
Mol. Mass.:
397.772
SMILES:
COc1ccc2cc3c(N)nn(C(=O)c4ccc(Cl)c(c4)[N+]([O-])=O)c3nc2c1
Structure:
Search PDB for entries with ligand similarity: