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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM67998
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
36150±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM67998
Synonyms:
(E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(2-furanylmethylamino)-2-oxoethyl]-3-indolyl]-2-propenamide | (E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(2-furfurylamino)-2-keto-ethyl]indol-3-yl]acrylamide | (E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(furan-2-ylmethylamino)-2-oxidanylidene-ethyl]indol-3-yl]prop-2-enamide | (E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(furan-2-ylmethylamino)-2-oxoethyl]indol-3-yl]prop-2-enamide | 2-Cyano-N-(2,3-dimethyl-phenyl)-3-(1-{[(furan-2-ylmethyl)-carbamoyl]-methyl}-1H-indol-3-yl)-acrylamide | MLS000569213 | SMR000177748 | cid_1140634
Type:
Small organic molecule
Emp. Form.:
C27H24N4O3
Mol. Mass.:
452.5045
SMILES:
Cc1cccc(NC(=O)C(=C\c2cn(CC(=O)NCc3ccco3)c3ccccc23)\C#N)c1C
Structure:
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