Reaction Details Report a problem with these data
Target
Ras-related protein Rab-7a
Ligand
BDBM54700
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54700
Synonyms:
3-phenyl-1-[4-(trifluoromethoxy)phenyl]-2-propyn-1-one | 3-phenyl-1-[4-(trifluoromethoxy)phenyl]prop-2-yn-1-one | 3-phenyl-1-[4-(trifluoromethyloxy)phenyl]prop-2-yn-1-one | UNM-0000306058 | cid_25109936
Type:
Small organic molecule
Emp. Form.:
C16H9F3O2
Mol. Mass.:
290.2367
SMILES:
FC(F)(F)Oc1ccc(cc1)C(=O)C#Cc1ccccc1
Structure:
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