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Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM54748
Substrate
n/a
Meas. Tech.
uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay
IC50
1090±n/a nM
Citation
 PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay (2009)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM54748
Synonyms:
3-hydroxy-6-(hydroxymethyl)-2-(pyridin-2-yl{[3-(trifluoromethyl)phenyl]amino}methyl)-4H-pyran-4-one | 3-hydroxy-6-(hydroxymethyl)-2-[2-pyridinyl-[3-(trifluoromethyl)anilino]methyl]-4-pyranone | 3-hydroxy-6-(hydroxymethyl)-2-[pyridin-2-yl-[3-(trifluoromethyl)anilino]methyl]pyran-4-one | 3-hydroxy-6-methylol-2-[2-pyridyl-[3-(trifluoromethyl)anilino]methyl]pyran-4-one | 6-(hydroxymethyl)-3-oxidanyl-2-[pyridin-2-yl-[[3-(trifluoromethyl)phenyl]amino]methyl]pyran-4-one | MLS000766783 | SMR000339679 | cid_4172393
Type:
Small organic molecule
Emp. Form.:
C19H15F3N2O4
Mol. Mass.:
392.3286
SMILES:
OCc1cc(=O)c(O)c(o1)C(Nc1cccc(c1)C(F)(F)F)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: