Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM55053
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3).
IC50
8845±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). PubChem Bioassay (2009)[AID] 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM55053
Synonyms:
2-hydroxy-6-methyl-3-[(E)-1-oxo-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enyl]-4-pyranone | 2-hydroxy-6-methyl-3-[(E)-3-(2,3,4,5,6-pentafluorophenyl)acryloyl]pyran-4-one | 2-hydroxy-6-methyl-3-[(E)-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enoyl]pyran-4-one | 6-methyl-2-oxidanyl-3-[(E)-3-[2,3,4,5,6-pentakis(fluoranyl)phenyl]prop-2-enoyl]pyran-4-one | MLS001164748 | SMR000539910 | cid_6070358
Type:
Small organic molecule
Emp. Form.:
C15H7F5O4
Mol. Mass.:
346.2057
SMILES:
Cc1cc(O)c(C(=O)C=Cc2c(F)c(F)c(F)c(F)c2F)c(=O)o1 |w:9.9|
Structure:
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