Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM268416
Substrate
n/a
Meas. Tech.
Nuclear receptor ROR-gamma
Temperature
298.15±n/a K
EC50
189±n/a nM
Comments
extracted
Citation
 Fauber, B; Gobbi, A Keto-imidazopyridine derivatives as RORc modulators US Patent  US9550771 Publication Date 1/24/2017 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM268416
Synonyms:
3,5-difluoro-4-[3-[2- (trifluoromethyl)benzoyl]imidazo [1,5-a]pyridin-1-yl]benzoic acid | US9550771, Example 15
Type:
Small organic molecule
Emp. Form.:
C22H11F5N2O3
Mol. Mass.:
446.3264
SMILES:
OC(=O)c1cc(F)c(-c2nc(C(=O)c3ccccc3C(F)(F)F)n3ccccc23)c(F)c1 |(-6.85,2.72,;-6.45,1.23,;-7.54,.14,;-4.96,.83,;-3.88,1.92,;-2.39,1.52,;-1.3,2.61,;-1.99,.03,;-.5,-.36,;.74,.54,;1.99,-.36,;3.48,.03,;4.57,-1.06,;3.88,1.52,;2.79,2.61,;3.19,4.1,;4.67,4.5,;5.76,3.41,;5.36,1.92,;6.45,.83,;7.54,-.26,;7.54,1.92,;5.36,-.26,;1.51,-1.83,;2.28,-3.16,;1.51,-4.5,;-.03,-4.5,;-.8,-3.16,;-.03,-1.83,;-3.08,-1.06,;-2.68,-2.54,;-4.57,-.66,)|
Structure:
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