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Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM268457
Substrate
n/a
Meas. Tech.
Nuclear receptor ROR-gamma
Temperature
298.15±n/a K
EC50
19.0±n/a nM
Comments
extracted
Citation
 Fauber, B; Gobbi, A Keto-imidazopyridine derivatives as RORc modulators US Patent  US9550771 Publication Date 1/24/2017 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM268457
Synonyms:
(3S,4R)-1-[3-(2-chloro-6- cyclopropyl-benzoyl)-6- (dimethylcarbamoyl)imidazo[1,5- a]pyridin-1-yl]-3-hydroxy- piperidine-4-carboxylic acid (RACEMATE) | US9550771, Example 56
Type:
Small organic molecule
Emp. Form.:
C26H27ClN4O5
Mol. Mass.:
510.969
SMILES:
CN(C)C(=O)c1ccc2c(nc(C(=O)c3c(Cl)cccc3C3CC3)n2c1)N1CC[C@H]([C@H](O)C1)C(O)=O |r|
Structure:
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