Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM56901
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM56901
Synonyms:
3-(2-chloro-6-fluoro-benzyl)-5-[1-(cyclohexanecarbonyl)-4-piperidyl]-2H-triazolo[4,5-d]pyrimidin-7-one | 3-[(2-chloranyl-6-fluoranyl-phenyl)methyl]-5-(1-cyclohexylcarbonylpiperidin-4-yl)-2H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one | 3-[(2-chloro-6-fluorophenyl)methyl]-5-[1-(cyclohexanecarbonyl)piperidin-4-yl]-2H-triazolo[4,5-d]pyrimidin-7-one | 3-[(2-chloro-6-fluorophenyl)methyl]-5-[1-[cyclohexyl(oxo)methyl]-4-piperidinyl]-2H-triazolo[4,5-d]pyrimidin-7-one | MLS000027923 | SMR000000951 | cid_654466 | {4-[3-(2-Chloro-6-fluoro-benzyl)-7-hydroxy-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]-piperidin-1-yl}-cyclohexyl-methanone
Type:
Small organic molecule
Emp. Form.:
C23H26ClFN6O2
Mol. Mass.:
472.943
SMILES:
Fc1cccc(Cl)c1Cn1nnc2c1nc([nH]c2=O)C1CCN(CC1)C(=O)C1CCCCC1
Structure:
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