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Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM49246
Substrate
n/a
Meas. Tech.
Chemical Antagonists IAP-family anti-apoptotic proteins
IC50
100000±n/a nM
Citation
 PubChem, PC Chemical Antagonists IAP-family anti-apoptotic proteins PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM49246
Synonyms:
(E)-1-(3-methoxyphenyl)-3-[(5-methyl-2-oxidanyl-phenyl)amino]prop-2-en-1-one | (E)-3-(2-hydroxy-5-methyl-anilino)-1-(3-methoxyphenyl)prop-2-en-1-one | (E)-3-(2-hydroxy-5-methylanilino)-1-(3-methoxyphenyl)-2-propen-1-one | (E)-3-(2-hydroxy-5-methylanilino)-1-(3-methoxyphenyl)prop-2-en-1-one | 3-[(2-hydroxy-5-methylphenyl)amino]-1-(3-methoxyphenyl)-2-propen-1-one | MLS000088060 | SMR000072274 | cid_2186107
Type:
Small organic molecule
Emp. Form.:
C17H17NO3
Mol. Mass.:
283.3218
SMILES:
COc1cccc(c1)C(=O)CC=Nc1cc(C)ccc1O |w:12.13|
Structure:
Search PDB for entries with ligand similarity: