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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61321
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
10305±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61321
Synonyms:
3-(1,3-benzodioxol-5-yl)-3-(5,7-dimethoxy-2-oxidanylidene-chromen-8-yl)-N,N-diethyl-propanamide | 3-(1,3-benzodioxol-5-yl)-3-(5,7-dimethoxy-2-oxo-1-benzopyran-8-yl)-N,N-diethylpropanamide | 3-(1,3-benzodioxol-5-yl)-3-(5,7-dimethoxy-2-oxochromen-8-yl)-N,N-diethylpropanamide | 3-(1,3-benzodioxol-5-yl)-N,N-diethyl-3-(2-keto-5,7-dimethoxy-chromen-8-yl)propionamide | MLS000879484 | SMR000465548 | cid_16746301
Type:
Small organic molecule
Emp. Form.:
C25H27NO7
Mol. Mass.:
453.4844
SMILES:
CCN(CC)C(=O)CC(c1ccc2OCOc2c1)c1c(OC)cc(OC)c2ccc(=O)oc12
Structure:
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