Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61372
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
10170±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61372
Synonyms:
MLS001030477 | N-(2-furanylmethyl)-2-methyl-1-(1-oxopropyl)-2,3-dihydroindole-5-sulfonamide | N-(2-furfuryl)-2-methyl-1-propionyl-indoline-5-sulfonamide | N-(furan-2-ylmethyl)-2-methyl-1-propanoyl-2,3-dihydroindole-5-sulfonamide | SMR000635401 | cid_3673460
Type:
Small organic molecule
Emp. Form.:
C17H20N2O4S
Mol. Mass.:
348.417
SMILES:
CCC(=O)N1C(C)Cc2cc(ccc12)S(=O)(=O)NCc1ccco1
Structure:
Search PDB for entries with ligand similarity: