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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM269004
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7.4±n/a
IC50
<1.50±n/a nM
Comments
extracted
Citation
 Nazare, M; Halland, N; Schmidt, F; Kleemann, H; Weiss, T; Saas, J; Struebing, C N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals US Patent  US9718825 Publication Date 8/1/2017 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM269004
Synonyms:
N-[4-(3-Amino-4-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-phenyl]-5-chloro-2,4-difluoro-benzenesulfonamide | US9718825, Example 447
Type:
Small organic molecule
Emp. Form.:
C18H13ClF2N6O2S
Mol. Mass.:
450.85
SMILES:
Cc1nc(nc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1
Structure:
Search PDB for entries with ligand similarity: