Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM62403
Substrate
n/a
Meas. Tech.
Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 2 (S1P2)
IC50
13750±n/a nM
Citation
 PubChem, PC Late stage counterscreen assay for S1P4 antagonists: Fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 2 (S1P2) PubChem Bioassay (2010)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM62403
Synonyms:
5-(2,5-dichlorophenyl)-N-(2,6-dimethyl-3-methylsulfonylphenyl)-2-furancarboxamide | 5-(2,5-dichlorophenyl)-N-(2,6-dimethyl-3-methylsulfonylphenyl)furan-2-carboxamide | 5-(2,5-dichlorophenyl)-N-(3-mesyl-2,6-dimethyl-phenyl)-2-furamide | 5-[2,5-bis(chloranyl)phenyl]-N-(2,6-dimethyl-3-methylsulfonyl-phenyl)furan-2-carboxamide | SR-02000000247 | SR-02000000247-1 | cid_44607582
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2NO4S
Mol. Mass.:
438.324
SMILES:
Cc1ccc(c(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: