Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM62192
Substrate
n/a
Meas. Tech.
SAR analysis of Agonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay
EC50
3854±n/a nM
Citation
 PubChem, PC SAR analysis of Agonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM62192
Synonyms:
(4Z)-4-[[(5-chloranylquinolin-8-yl)amino]methylidene]-5-methyl-2-(4-methylphenyl)pyrazol-3-one | (4Z)-4-[[(5-chloro-8-quinolinyl)amino]methylidene]-5-methyl-2-(4-methylphenyl)-3-pyrazolone | (4Z)-4-[[(5-chloro-8-quinolyl)amino]methylene]-5-methyl-2-(p-tolyl)-2-pyrazolin-3-one | (4Z)-4-[[(5-chloroquinolin-8-yl)amino]methylidene]-5-methyl-2-(4-methylphenyl)pyrazol-3-one | MLS-0425693.0001 | cid_44537710
Type:
Small organic molecule
Emp. Form.:
C21H17ClN4O
Mol. Mass.:
376.839
SMILES:
Cc1[nH]n(-c2ccc(C)cc2)c(=O)c1C=Nc1ccc(Cl)c2cccnc12 |w:15.17|
Structure:
Search PDB for entries with ligand similarity: