Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63119
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63119
Synonyms:
4-[[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]amino]benzoic acid ethyl ester | 4-[[(E)-3-keto-3-(4-methoxyphenyl)prop-1-enyl]amino]benzoic acid ethyl ester | MLS000578680 | SMR000186173 | cid_2248752 | ethyl 4-[[(E)-3-(4-methoxyphenyl)-3-oxidanylidene-prop-1-enyl]amino]benzoate | ethyl 4-[[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]amino]benzoate | ethyl 4-{[3-(4-methoxyphenyl)-3-oxo-1-propen-1-yl]amino}benzoate
Type:
Small organic molecule
Emp. Form.:
C19H19NO4
Mol. Mass.:
325.3585
SMILES:
CCOC(=O)c1ccc(cc1)N=CCC(=O)c1ccc(OC)cc1 |w:11.11|
Structure:
Search PDB for entries with ligand similarity: