Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM43388
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
14439±1054 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM43388
Synonyms:
(E)-4-[2-[2-[[(E)-4-ethoxy-1,4-dioxobut-2-enyl]amino]phenyl]anilino]-4-oxo-2-butenoic acid ethyl ester | (E)-4-[2-[2-[[(E)-4-ethoxy-4-keto-but-2-enoyl]amino]phenyl]anilino]-4-keto-but-2-enoic acid ethyl ester | MLS000574522 | SMR000195187 | cid_5730500 | diethyl 4,4'-(2,2'-biphenyldiyldiimino)bis(4-oxo-2-butenoate) | ethyl (E)-4-[2-[2-[[(E)-4-ethoxy-4-oxobut-2-enoyl]amino]phenyl]anilino]-4-oxobut-2-enoate | ethyl (E)-4-[[2-[2-[[(E)-4-ethoxy-4-oxidanylidene-but-2-enoyl]amino]phenyl]phenyl]amino]-4-oxidanylidene-but-2-enoate
Type:
Small organic molecule
Emp. Form.:
C24H24N2O6
Mol. Mass.:
436.4572
SMILES:
CCOC(=O)\C=C\C(=O)Nc1ccccc1-c1ccccc1NC(=O)\C=C\C(=O)OCC
Structure:
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