Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63168
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63168
Synonyms:
4-methyl-2-[[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]amino]-5-(phenylmethyl)thiophene-3-carboxamide | 4-methyl-2-[[(Z)-(2-oxo-1-naphthalenylidene)methyl]amino]-5-(phenylmethyl)-3-thiophenecarboxamide | 5-Benzyl-2-[(2-hydroxy-naphthalen-1-ylmethylene)-amino]-4-methyl-thiophene-3-carboxylic acid amide | 5-benzyl-2-[[(Z)-(2-keto-1-naphthylidene)methyl]amino]-4-methyl-thiophene-3-carboxamide | 5-benzyl-4-methyl-2-[[(Z)-(2-oxonaphthalen-1-ylidene)methyl]amino]thiophene-3-carboxamide | MLS000555066 | SMR000171736 | cid_5432072
Type:
Small organic molecule
Emp. Form.:
C24H20N2O2S
Mol. Mass.:
400.493
SMILES:
Cc1c(Cc2ccccc2)sc(N=Cc2c(O)ccc3ccccc23)c1C(N)=O |w:12.12|
Structure:
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