Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63203
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
4033±3646 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63203
Synonyms:
2-[2-[(Z)-2-nitroethenyl]phenoxy]acetic acid ethyl ester | 2-[2-[(Z)-2-nitrovinyl]phenoxy]acetic acid ethyl ester | MLS000586023 | SMR000204386 | cid_5286552 | ethyl 2-[2-[(Z)-2-nitroethenyl]phenoxy]acetate | ethyl 2-[2-[(Z)-2-nitroethenyl]phenoxy]ethanoate | ethyl {2-[(Z)-2-nitrovinyl]phenoxy}acetate
Type:
Small organic molecule
Emp. Form.:
C12H13NO5
Mol. Mass.:
251.2353
SMILES:
CCOC(=O)COc1ccccc1\C=C/[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: