Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63382
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63382
Synonyms:
MLS000587659 | N-[5-[2-[2-(2-furanylmethylidene)hydrazinyl]-2-oxoethyl]-1,3,4-thiadiazol-2-yl]-2-methylbenzamide | N-[5-[2-[2-(furan-2-ylmethylidene)hydrazinyl]-2-oxidanylidene-ethyl]-1,3,4-thiadiazol-2-yl]-2-methyl-benzamide | N-[5-[2-[2-(furan-2-ylmethylidene)hydrazinyl]-2-oxoethyl]-1,3,4-thiadiazol-2-yl]-2-methylbenzamide | N-[5-[2-[N'-(2-furfurylidene)hydrazino]-2-keto-ethyl]-1,3,4-thiadiazol-2-yl]-2-methyl-benzamide | N-{5-[1-Furan-2-yl-meth-(E)-ylidene-hydrazinocarbonylmethyl]-[1,3,4]thiadiazol-2-yl}-2-methyl-benzamide | SMR000211646 | cid_1420471
Type:
Small organic molecule
Emp. Form.:
C17H15N5O3S
Mol. Mass.:
369.398
SMILES:
Cc1ccccc1C(=O)Nc1nnc(CC(=O)NN=Cc2ccco2)s1
Structure:
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