Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63393
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63393
Synonyms:
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-[3-[(2-fluorophenyl)sulfamoyl]phenyl]acetamide | 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-[3-[(2-fluorophenyl)sulfamoyl]phenyl]acetamide | 2-(2,6-diketo-1,3-dimethyl-purin-7-yl)-N-[3-[(2-fluorophenyl)sulfamoyl]phenyl]acetamide | 2-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]-N-[3-[(2-fluorophenyl)sulfamoyl]phenyl]ethanamide | MLS000417452 | SMR000242643 | cid_3310491
Type:
Small organic molecule
Emp. Form.:
C21H19FN6O5S
Mol. Mass.:
486.476
SMILES:
Cn1c2ncn(CC(=O)Nc3cccc(c3)S(=O)(=O)Nc3ccccc3F)c2c(=O)n(C)c1=O
Structure:
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