Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63396
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63396
Synonyms:
MLS000700011 | N-[2-(1,2,3-thiadiazol-4-ylcarbonylamino)phenyl]-1,2,3-thiadiazole-4-carboxamide | N-[2-(thiadiazole-4-carbonylamino)phenyl]thiadiazole-4-carboxamide | N-[2-[[oxo(4-thiadiazolyl)methyl]amino]phenyl]-4-thiadiazolecarboxamide | N-{2-[(1,2,3-thiadiazol-4-ylcarbonyl)amino]phenyl}-1,2,3-thiadiazole-4-carboxamide | SMR000229711 | cid_4462938
Type:
Small organic molecule
Emp. Form.:
C12H8N6O2S2
Mol. Mass.:
332.361
SMILES:
O=C(Nc1ccccc1NC(=O)c1csnn1)c1csnn1
Structure:
Search PDB for entries with ligand similarity: