Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63403
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63403
Synonyms:
3-[(3,5-dichloro-2-pyridinyl)hydrazo]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[2-(3,5-dichloropyridin-2-yl)hydrazino]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[2-(3,5-dichloropyridin-2-yl)hydrazinyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[2-[3,5-bis(chloranyl)pyridin-2-yl]hydrazinyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[N'-(3,5-dichloro-2-pyridyl)hydrazino]-1-(4-methoxyphenyl)pyrrolidine-2,5-quinone | MLS000728774 | SMR000307052 | cid_4673902
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N4O3
Mol. Mass.:
381.213
SMILES:
COc1ccc(cc1)-n1c(O)cc(NNc2ncc(Cl)cc2Cl)c1O
Structure:
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