Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM63529
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM63529
Synonyms:
MLS000707868 | SMR000288935 | [4-(2-hydroxy-3-pyrrolidin-1-ylpropoxy)phenyl]-phenylmethanone | [4-(2-hydroxy-3-pyrrolidino-propoxy)phenyl]-phenyl-methanone | [4-(2-oxidanyl-3-pyrrolidin-1-yl-propoxy)phenyl]-phenyl-methanone | [4-[2-hydroxy-3-(1-pyrrolidinyl)propoxy]phenyl]-phenylmethanone | cid_3157241
Type:
Small organic molecule
Emp. Form.:
C20H23NO3
Mol. Mass.:
325.4015
SMILES:
OC(COc1ccc(cc1)C(=O)c1ccccc1)CN1CCCC1
Structure:
Search PDB for entries with ligand similarity: