Reaction Details Report a problem with these data
Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM64878
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
>150000±0 nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM64878
Synonyms:
3-(4-Methyl-benzyl)-5-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol | 3-(4-methylbenzyl)-5-(1-tosyl-4-piperidyl)-2H-triazolo[4,5-d]pyrimidin-7-one | 3-[(4-methylphenyl)methyl]-5-[1-(4-methylphenyl)sulfonyl-4-piperidinyl]-2H-triazolo[4,5-d]pyrimidin-7-one | 3-[(4-methylphenyl)methyl]-5-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-2H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one | 3-[(4-methylphenyl)methyl]-5-[1-(4-methylphenyl)sulfonylpiperidin-4-yl]-2H-triazolo[4,5-d]pyrimidin-7-one | MLS000035422 | SMR000007393 | cid_648893
Type:
Small organic molecule
Emp. Form.:
C24H26N6O3S
Mol. Mass.:
478.567
SMILES:
Cc1ccc(Cn2nnc3c2nc([nH]c3=O)C2CCN(CC2)S(=O)(=O)c2ccc(C)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: