Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54510
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
8251±952 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54510
Synonyms:
5-chloranyl-N-[4-[ethyl(phenyl)sulfamoyl]phenyl]-2-methylsulfonyl-pyrimidine-4-carboxamide | 5-chloro-N-[4-[ethyl(phenyl)sulfamoyl]phenyl]-2-mesyl-pyrimidine-4-carboxamide | 5-chloro-N-[4-[ethyl(phenyl)sulfamoyl]phenyl]-2-methylsulfonyl-4-pyrimidinecarboxamide | 5-chloro-N-[4-[ethyl(phenyl)sulfamoyl]phenyl]-2-methylsulfonylpyrimidine-4-carboxamide | MLS001116357 | SMR000625580 | cid_16012863
Type:
Small organic molecule
Emp. Form.:
C20H19ClN4O5S2
Mol. Mass.:
494.972
SMILES:
CCN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(ncc2Cl)S(C)(=O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: