Reaction Details
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Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM65760
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF
IC50
17500±n/a nM
Citation
PubChem, PC SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
Inhibitor
Name:
BDBM65760
Synonyms:
2-(2-furanyl)-4-quinolinecarboxylic acid [1-[(4-methoxyphenyl)methylamino]-1-oxopropan-2-yl] ester | 2-(2-furyl)cinchoninic acid [2-keto-1-methyl-2-(p-anisylamino)ethyl] ester | MLS-0315876.0001 | [1-[(4-methoxyphenyl)methylamino]-1-oxidanylidene-propan-2-yl] 2-(furan-2-yl)quinoline-4-carboxylate | [1-[(4-methoxyphenyl)methylamino]-1-oxopropan-2-yl] 2-(furan-2-yl)quinoline-4-carboxylate | cid_16252818
Type:
Small organic molecule
Emp. Form.:
C25H22N2O5
Mol. Mass.:
430.4526
SMILES:
COc1ccc(CNC(=O)C(C)OC(=O)c2cc(nc3ccccc23)-c2ccco2)cc1
Structure:
