Reaction Details
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Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM65797
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF
IC50
5590±n/a nM
Citation
PubChem, PC SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
Inhibitor
Name:
BDBM65797
Synonyms:
2-(2-furanyl)-N-(4-phenylcyclohexyl)-4-quinolinecarboxamide | 2-(2-furyl)-N-(4-phenylcyclohexyl)cinchoninamide | 2-(furan-2-yl)-N-(4-phenylcyclohexyl)quinoline-4-carboxamide | VU0409723-1 | cid_44602313
Type:
Small organic molecule
Emp. Form.:
C26H24N2O2
Mol. Mass.:
396.481
SMILES:
O=C(NC1CCC(CC1)c1ccccc1)c1cc(nc2ccccc12)-c1ccco1 |(9.52,1,;8.18,1.77,;6.85,1,;6.85,-.54,;5.52,-1.31,;5.52,-2.85,;6.85,-3.62,;8.18,-2.85,;8.18,-1.31,;6.85,-5.16,;5.52,-5.93,;5.52,-7.47,;6.85,-8.24,;8.18,-7.47,;8.18,-5.93,;8.18,3.31,;6.85,4.08,;6.85,5.62,;8.18,6.39,;9.52,5.62,;10.9,6.44,;12.29,5.65,;12.29,4.05,;10.9,3.26,;9.52,4.08,;5.52,6.39,;4.11,5.76,;3.08,6.91,;3.85,8.24,;5.36,7.92,)|
Structure:
