Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM66145
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase
IC50
>59640±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta lactamase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31513.38
Organism:
Pseudomonas aeruginosa
Description:
gi_114881106
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM66145
Synonyms:
MLS000948311 | N-[4-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl]oxolane-2-carboxamide | N-[4-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl]tetrahydrofuran-2-carboxamide | N-[4-[oxo-[4-(trifluoromethyl)anilino]methyl]phenyl]-2-oxolanecarboxamide | SMR000621339 | cid_15994190
Type:
Small organic molecule
Emp. Form.:
C19H17F3N2O3
Mol. Mass.:
378.3451
SMILES:
FC(F)(F)c1ccc(NC(=O)c2ccc(NC(=O)C3CCCO3)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: