Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM66118
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase
IC50
36414±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM66118
Synonyms:
(6E)-5-azanylidene-6-[(4-oxidanylidenechromen-3-yl)methylidene]-[1,3]thiazolo[3,2-a]pyrimidin-7-one | (6E)-5-imino-6-[(4-ketochromen-3-yl)methylene]thiazolo[3,2-a]pyrimidin-7-one | (6E)-5-imino-6-[(4-oxo-1-benzopyran-3-yl)methylidene]-7-thiazolo[3,2-a]pyrimidinone | (6E)-5-imino-6-[(4-oxochromen-3-yl)methylidene]-[1,3]thiazolo[3,2-a]pyrimidin-7-one | 5-Imino-6-[1-(4-oxo-4H-chromen-3-yl)-meth-(E)-ylidene]-5,6-dihydro-thiazolo[3,2-a]pyrimidin-7-one | MLS000332035 | SMR000221459 | cid_2037851
Type:
Small organic molecule
Emp. Form.:
C16H9N3O3S
Mol. Mass.:
323.326
SMILES:
N=C1N2C=CSC2=NC(=O)\C1=C\c1coc2ccccc2c1=O |c:3,7|
Structure:
Search PDB for entries with ligand similarity: