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Target
Beta-lactamase
Ligand
BDBM51212
Substrate
n/a
Meas. Tech.
Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase
IC50
14107±n/a nM
Citation
 PubChem, PC Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase PubChem Bioassay (2010)[AID] 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM51212
Synonyms:
2-(2-furanylmethyl)-6-hydroxybenzo[de]isoquinoline-1,3-dione | 2-(2-furfuryl)-6-hydroxy-benzo[de]isoquinoline-1,3-quinone | 2-(2-furylmethyl)-6-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione | 2-(furan-2-ylmethyl)-6-hydroxybenzo[de]isoquinoline-1,3-dione | 2-(furan-2-ylmethyl)-6-oxidanyl-benzo[de]isoquinoline-1,3-dione | MLS000686736 | SMR000339831 | cid_6028554
Type:
Small organic molecule
Emp. Form.:
C17H11NO4
Mol. Mass.:
293.2735
SMILES:
Oc1ccc2C(=O)N(Cc3ccco3)C(=O)c3cccc1c23
Structure:
Search PDB for entries with ligand similarity: