Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67106
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM67106
Synonyms:
2-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]-N-(2-methoxy-5-methylphenyl)-2-phenylacetamide | 2-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-N-(2-methoxy-5-methyl-phenyl)-2-phenyl-ethanamide | 2-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-N-(2-methoxy-5-methylphenyl)-2-phenylacetamide | 2-[4-(4-fluorophenyl)sulfonylpiperazino]-N-(2-methoxy-5-methyl-phenyl)-2-phenyl-acetamide | SR-03000000775-1 | cid_4882818
Type:
Small organic molecule
Emp. Form.:
C26H28FN3O4S
Mol. Mass.:
497.582
SMILES:
COc1ccc(C)cc1NC(=O)C(N1CCN(CC1)S(=O)(=O)c1ccc(F)cc1)c1ccccc1
Structure:
