Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67127
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM67127
Synonyms:
N-[2-keto-4-[[(4-keto-1H-quinazolin-2-yl)thio]methyl]chromen-7-yl]carbamic acid ethyl ester | N-[2-oxo-4-[[(4-oxo-1H-quinazolin-2-yl)thio]methyl]-1-benzopyran-7-yl]carbamic acid ethyl ester | SR-03000000852-1 | cid_2475088 | ethyl N-[2-oxidanylidene-4-[(4-oxidanylidene-1H-quinazolin-2-yl)sulfanylmethyl]chromen-7-yl]carbamate | ethyl N-[2-oxo-4-[(4-oxo-1H-quinazolin-2-yl)sulfanylmethyl]chromen-7-yl]carbamate
Type:
Small organic molecule
Emp. Form.:
C21H17N3O5S
Mol. Mass.:
423.442
SMILES:
CCOC(=O)Nc1ccc2c(CSc3nc4ccccc4c(=O)[nH]3)cc(=O)oc2c1
Structure:
