Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67137
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
 PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM67137
Synonyms:
3-[[4-(1-adamantyl)-1,3-thiazol-2-yl]methyl]-2-[(4-methylpiperazin-1-yl)methylidene]-1H-quinazolin-4-one | 3-[[4-(1-adamantyl)-2-thiazolyl]methyl]-2-[(4-methyl-1-piperazinyl)methylidene]-1H-quinazolin-4-one | 3-[[4-(1-adamantyl)thiazol-2-yl]methyl]-2-[(4-methylpiperazino)methylene]-1H-quinazolin-4-one | SR-03000001029-1 | cid_44202995
Type:
Small organic molecule
Emp. Form.:
C28H35N5OS
Mol. Mass.:
489.675
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)c1csc(Cn2c(CN3CCN(C)CC3)nc3ccccc3c2=O)n1 |TLB:8:1:12:6.9.5,8:6:12:1.11.2,THB:5:6:11:3.12.2|
Structure:
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